Precautions Do not dispense dose applicator tubes without complete safety and administration information. Use with caution in sick, debilitated, or underweight animals. The safety of Advantage Multi has not been established in breeding, pregnant, or lactating animals. The safe use of Advantage Multi has not been established in puppies and dogs less than 7 weeks of age or less than 3 lbs. body weight. Prior to administration of Advantage Multi, dogs should be tested for existing heartworm infection. At the discretion of the veterinarian, infected dogs should be treated with an adulticide to remove adult heartworms. The safety of Advantage Multi for Dogs has not been evaluated when administered on the same day as an adulticide. Advantage Multi for Dogs is not effective against adult D. Immitis.